A neutrophil-mesangial cell axis promotes glomerular injury in lupus nephritis
NET-producing neutrophils infiltrate the kidney early in LN. NET-derived citH3 activates MC through Toll-like receptor 4, promoting inflammation and fibrosis, establishing a novel NET-MC axis that may represent a mechanistic driver and therapeutic target in LN.
Authors
- Norio Hanata (ORCID: https://orcid.org/0000-0002-0195-4039)
- Mariana J. Kaplan (ORCID: https://orcid.org/0000-0003-2968-0815)
- Sarfaraz Hasni (ORCID: https://orcid.org/0000-0002-4164-8837)
- Zerai Manna (ORCID: https://orcid.org/0000-0003-1318-2213)
- Kan Jiang (ORCID: https://orcid.org/0009-0002-1402-0355)
- Carmelo Carmona‐Rivera (ORCID: https://orcid.org/0000-0002-7706-1464)
- Davide Randazzo (ORCID: https://orcid.org/0000-0002-2000-3060)
- Meryl Waldman (ORCID: https://orcid.org/0000-0001-8698-0502)
- Victoria Hoffmann
Institutions
- National Institutes of Health (US)
- Office of Science (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Office of Research Services (US)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ard.2025.11.011
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- Office of Science
- National Cancer Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases