Effects of emodepside on single-channel properties of Onchocerca volvulus SLO-1A (BK) potassium channels

This study successfully expressed Ovo-SLO-1A in HEK293 cells, measured the conductance of the main open-state, and detected the presence of subconductance states and flickering openings. The increased amplitudes of the single-channel currents, open burst times, and open probabilities provides insights into the complex kinetics by which emodepside increases Slo-1K currents and illustrates the dynamic actions of emodepside on Ovo-SLO-1A.