Sex differences in the blood metabolome of extremely preterm infants: a pilot study on the impact of antibiotic therapy
These findings demonstrate that standard empirical antibiotic therapies for prematurity exert sex-dependent effects on neonatal metabolism, with antibiotics amplifying AC alterations in males. Our results underscore the need to consider sex as a key biological variable in neonatal pharmaco-metabolomics and highlight the potential of metabolic profiling to optimize individualized treatments in EPI.
Authors
- Marianna Caterino (ORCID: https://orcid.org/0000-0001-6035-8213)
- Ilaria Campesi (ORCID: https://orcid.org/0000-0002-1681-6448)
- Mariangela Valentina Puci (ORCID: https://orcid.org/0000-0001-5656-6845)
- Michele Costanzo (ORCID: https://orcid.org/0000-0002-6386-2009)
- Margherita Ruoppolo (ORCID: https://orcid.org/0000-0002-7364-0602)
- Giovanni Sotgiu (ORCID: https://orcid.org/0000-0002-1600-4474)
- Sabrina Bianco
- Flavia Franconi (ORCID: https://orcid.org/0000-0002-1116-2297)
Institutions
- University of Sassari (IT)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s13293-025-00798-1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00