CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway

Casein kinase 1δ (CK1δ, encoded by casein kinase 1 delta) (CSNK1D) is a serine/threonine protein kinase closely associated with cancer development. However, the biological functions of CSNK1D in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study identifies CSNK1D as a previously unrecognized yet crucial regulator in the progression of HNSCC. CSNK1D expression levels were upregulated in tumor tissues and the up-regulation was positively correlated with poor survival in patients with HNSCC. Moreover, CSNK1D selectively bound SHH and PTCH1, and regulated the stability of the CSNK1D-SHH-PTCH1 complex to control the GLI1-BCL2 axis, leading to the downstream activation of the hedgehog pathway. SB-203580 could target and inhibit CSNK1D, offering new perspectives for the clinical treatment of HNSCC. Overall, CSNK1D is underscored as a vital oncogenic driver and promising therapeutic target for HNSCC.

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Publication Details

Journal
Cell Death and Disease
Published
2025-12-06
DOI
https://doi.org/10.1038/s41419-025-08276-7
Primary Topic
Hedgehog Signaling Pathway Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway

Yu‐Xiong Su, Tong Ji, Jinhai Ye, Zheqi Liu et al.
Cell Death and Disease
Hedgehog Signaling Pathway Studies
article

CSNK1D inhibition suppresses head and neck squamous cell carcinoma progression through SHH and PTCH1 pathway

Yu‐Xiong Su, Tong Ji, Jinhai Ye, Zheqi Liu, Chengzhong Lin, Yun Zhu, Canhua Jiang, Xiang Li, Yang Li, Yu Zhang, Yang Wang, Jun Gao
article en

Abstract

Casein kinase 1δ (CK1δ, encoded by casein kinase 1 delta) (CSNK1D) is a serine/threonine protein kinase closely associated with cancer development. However, the biological functions of CSNK1D in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study identifies CSNK1D as a previously unrecognized yet crucial regulator in the progression of HNSCC. CSNK1D expression levels were upregulated in tumor tissues and the up-regulation was positively correlated with poor survival in patients with HNSCC. Moreover, CSNK1D selectively bound SHH and PTCH1, and regulated the stability of the CSNK1D-SHH-PTCH1 complex to control the GLI1-BCL2 axis, leading to the downstream activation of the hedgehog pathway. SB-203580 could target and inhibit CSNK1D, offering new perspectives for the clinical treatment of HNSCC. Overall, CSNK1D is underscored as a vital oncogenic driver and promising therapeutic target for HNSCC.

Cell Death and DiseaseVol. 17(1)
Central South University (CN), Fudan University (CN), Shanghai Stomatological Hospital (CN), Zhongshan Hospital (CN), Xiangya Hospital Central South University (CN), Nanjing Medical University (CN), University of Hong Kong (HK)
Jiangsu Commission of Health, National Natural Science Foundation of China
Openalex Percentile: Top 65%
Hedgehog Signaling Pathway Studies
DOIOpen Access PDFOpenAlex
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