Thrombomodulin and CXCL6 Altered Expression in Preeclampsia: Serum‐Placental Biomarker Correlations and Clinical Significance
In pregnant women with PE, the serum levels of THBD and CXCL6 are increased, whereas their expression in placental tissue is decreased. CXCL6 emerges as an independent risk factor for PE, with expression patterns independent of gestational age confounding, while THBD shows PE-specific gestational age-related effects that provide additional insights into disease pathophysiology. These findings indicate that the inflammatory response and insufficient trophoblast invasion may play important roles in the pathogenesis of PE, providing a new theoretical basis for the early diagnosis and targeted intervention of PE.
Authors
- Juanjuan Chen (ORCID: https://orcid.org/0000-0002-6199-7807)
- Xiaobao Lai
- Zhihua Liao
- Mengqi Lin
- Xin Zeng (ORCID: https://orcid.org/0009-0002-5881-8182)
- Lulu Sheng (ORCID: https://orcid.org/0000-0002-5327-8933)
- Weiming Yang
- Pan Huang (ORCID: https://orcid.org/0000-0003-3012-1818)
- Shan Wu (ORCID: https://orcid.org/0009-0002-6683-7359)
Institutions
- Nanchang University (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/aji.70192
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangxi Provincial Department of Science and Technology
- Health Commission of Jiangxi Province