Performance of GPT-5 Frontier Models in Ophthalmology Question Answering
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Authors
- Sumit Sharma (ORCID: https://orcid.org/0000-0001-5769-0717)
- Pearse A. Keane (ORCID: https://orcid.org/0000-0002-9239-745X)
- Danny A. Mammo (ORCID: https://orcid.org/0000-0002-7496-5118)
- Bing Yu Chen (ORCID: https://orcid.org/0000-0003-4049-7528)
- Daniel Milad (ORCID: https://orcid.org/0000-0002-0693-3421)
- Qingyu Chen (ORCID: https://orcid.org/0000-0002-6036-1516)
- Jonathan El‐Khoury (ORCID: https://orcid.org/0000-0003-3186-2351)
- Renaud Duval (ORCID: https://orcid.org/0000-0002-3845-3318)
- Yih Chung Tham (ORCID: https://orcid.org/0000-0002-6752-797X)
- Samir Touma
- Mertcan Sevgi
- David Mikhail (ORCID: https://orcid.org/0009-0009-0831-1915)
- Sunil K. Srivastava
- Fares Antaki
Institutions
- Cleveland Clinic (US)
- National University of Singapore (SG)
- University of Toronto (CA)
- Singapore National Eye Center (SG)
- Hôpital Maisonneuve-Rosemont (CA)
- Yale University (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Centre Hospitalier de l’Université de Montréal (CA)
- Moorfields Eye Hospital (GB)
- Cleveland Eye Clinic (US)
- University College London (GB)
- Case Western Reserve University (US)
- Université de Montréal (CA)
Publication Details
- Journal
- Ophthalmology Science
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.xops.2025.101034
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cleveland Clinic
- American Academy of Ophthalmology
- Apellis Pharmaceuticals
- Moorfields Eye Charity
- National Institutes of Health
- Alcon Research Institute