Lesion topography shapes motor thresholds in brain tumor patients
Motor cortex excitability in brain tumor patients is shaped by the functional integrity of interconnected cortical hubs. Disruption of inhibitory (e.g., sensory cortex) or facilitatory (e.g., premotor cortex) inputs to MC can modulate excitability in opposing directions. The combined use of nTMS and VLSM enables a network-level understanding of tumor-induced excitability changes and supports individualized surgical planning based on lesion topography.
Authors
- Marcos Tatagiba
- Alexander Stark (ORCID: https://orcid.org/0000-0003-2611-0841)
- Georgios Naros (ORCID: https://orcid.org/0000-0003-4807-6234)
- Kathrin Machetanz (ORCID: https://orcid.org/0000-0002-5350-4574)
- Mykola Gorbachuk
- Athanasios Gkampenis (ORCID: https://orcid.org/0009-0005-0668-425X)
- Sophie Wang
- Aldo Spolaore (ORCID: https://orcid.org/0009-0002-9858-8377)
- Kateryna Goloshchapova
Institutions
- University of Tübingen (DE)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.nicl.2025.103924
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00