Innovative practices and reflections on the development of hospital-led co-constructed state key laboratories

Focusing on the development of the State Key Laboratory for Complex, Severe, and Rare Diseases since its restructuring, this paper explores its practices in fully integrating the advantages of multi-party resources, constructing a medical engineering integrated scientific research system, and innovating management mechanisms. Since the restructuring, the laboratory has focused on three core research directions (complex diseases, severe diseases, and rare diseases), and achieved remarkable results in research projects, academic papers, patent authorizations, and achievement transformation. Its recent representative achievements cover state strategic medical research fields such as pancreatic cancer mechanism research, therapeutic strategies for immunodeficiency-related sepsis, and large models for rare diseases. In the future, the laboratory will continue to benchmark against international advanced standards, strengthen open cooperation and talent echelon construction, accelerate the clinical transformation of scientific research achievements, and help enhance the hospital's original innovation capability and international influence in the field of Complex, Severe, and Rare Diseases.