PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms

This study identifies a novel signalling axis-GRK4/Nedd4L/ENaC-in PM2.5-induced hypertension, highlighting epigenetic and post-translational regulatory mechanisms. These findings provide mechanistic insights into environmentally mediated hypertensive pathogenesis and suggest potential therapeutic targets for PM2.5-related cardiovascular diseases.

Authors

Xi Lu (ORCID: https://orcid.org/0000-0002-5063-3776)
Dan Liu (ORCID: https://orcid.org/0000-0002-9971-2264)
Yong Li (ORCID: https://orcid.org/0009-0007-9844-1187)
Jiahui Jiang (ORCID: https://orcid.org/0009-0001-9020-364X)
Li Su
Tao Jiang (ORCID: https://orcid.org/0009-0007-6524-5382)
Te Yang

Institutions

Dalian Medical University (CN)
Second Affiliated Hospital of Chongqing Medical University (CN)
Chongqing Emergency Medical Center (CN)
First People's Hospital of Chongqing (CN)
Chongqing Medical University (CN)

Publication Details

Journal: Blood Pressure
Published: 2025-12-06
DOI: https://doi.org/10.1080/08037051.2025.2600133
Primary Topic: Endoplasmic Reticulum Stress and Disease
Type: article
Field-Weighted Citation Impact: 0.00

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article

PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms

Xi Lu, Dan Liu, Yong Li, Jiahui Jiang et al.

Dec 6, 2025

Blood Pressure

Endoplasmic Reticulum Stress and Disease

article

PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms

Xi Lu, Dan Liu, Yong Li, Jiahui Jiang, Li Su, Tao Jiang, Te Yang

December 6, 2025article en

Abstract

This study identifies a novel signalling axis-GRK4/Nedd4L/ENaC-in PM2.5-induced hypertension, highlighting epigenetic and post-translational regulatory mechanisms. These findings provide mechanistic insights into environmentally mediated hypertensive pathogenesis and suggest potential therapeutic targets for PM2.5-related cardiovascular diseases.

Blood PressureVol. 34(1)

Dalian Medical University (CN), Second Affiliated Hospital of Chongqing Medical University (CN), Chongqing Emergency Medical Center (CN), First People's Hospital of Chongqing (CN), Chongqing Medical University (CN)

Openalex Percentile: Top 59%

Endoplasmic Reticulum Stress and Disease

DOI Open Access PDF OpenAlex

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PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms — Xi Lu, Dan Liu, et al. · Blood Pressure (2025) | TGRS Research Map | TGRS