Proteomic Identification of ALDOA as a Pathogenic TDP-43 Interaction Partner in ALS
TDP-43 interacts with ALDOA in ALS, and the TDP-43<sup>M337V</sup> mutation significantly promotes ALDOA expression, suggesting that ALDOA may be involved in the pathogenesis of TDP-43-mediated ALS. These findings provide new insights into the pathogenesis of ALS and highlight a potential therapeutic target.
Authors
- Yuxuan Yong (ORCID: https://orcid.org/0009-0003-9526-9335)
- Jinfeng Deng
- Kaixin Yan (ORCID: https://orcid.org/0009-0004-9430-0975)
- Fangfang Bi (ORCID: https://orcid.org/0000-0002-6770-709X)
Institutions
- Xinjiang Medical University (CN)
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Degenerative Neurological and Neuromuscular Disease
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dnnd.s535954
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Xinjiang Medical University