Impact of accelerometer epoch summary measure on associations between physical activity and all-cause mortality in Whitehall II and UK Biobank

Accelerometer data are commonly reduced into epoch summary measures (ESMs) for analysis, e.g. ENMO (Euclidean Norm Minus One), MAD (Mean Amplitude Deviation), MIMS (Monitor Independent Movement Summary) or Counts. We compared associations with all-cause mortality of the volume and intensity of physical activity when derived from those four measures in the Whitehall II and UK Biobank cohorts. Volume (Average Acceleration, AvAcc) and intensity (Intensity Gradient, IG) were derived from each ESM. Associations with mortality were estimated using Cox models. 3733 (25.1% female, median age 68.3 years) and 89,848 (56.4% female, 63.5 years) participants were included from Whitehall II and UK Biobank, respectively. Median (IQR) follow-up was 11.0 (10.7, 11.3) and 8.0 (7.5, 8.5) years, with 563 (15.1%) and 3656 (4.1%) deaths. Associations with mortality were largely consistent between ESMs with the lowest mortality risk for those high (above the median) in both AvAcc and IG (Whitehall: HR = 0.59-0.68; Biobank: 0.55-0.61, reference: low/low), and IG associated with lower mortality risk, irrespective of AvAcc. AvAcc was associated with lower mortality irrespective of IG in Biobank only. In conclusion, associations of AvAcc and IG with mortality are broadly consistent across common ESMs, supporting comparability of activity-health findings across studies using different ESMs.

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Publication Details

Journal
Scientific Reports
Published
2025-12-06
DOI
https://doi.org/10.1038/s41598-025-30237-5
Primary Topic
Physical Activity and Health
Type
article
Field-Weighted Citation Impact
0.00

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article

Impact of accelerometer epoch summary measure on associations between physical activity and all-cause mortality in Whitehall II and UK Biobank

Lauren B. Sherar, SEBASTIEN F. M. CHASTIN, Cameron Razieh, Bjørge Herman Hansen et al.
Scientific Reports
Physical Activity and Health
article

Impact of accelerometer epoch summary measure on associations between physical activity and all-cause mortality in Whitehall II and UK Biobank

Lauren B. Sherar, SEBASTIEN F. M. CHASTIN, Cameron Razieh, Bjørge Herman Hansen, Ian Meneghel Danilevicz, Sèverine Sabia, Paddy C. Dempsey, Alex V. Rowlands, Henrik R. Eckmann, Sam Vidil
article en

Abstract

Accelerometer data are commonly reduced into epoch summary measures (ESMs) for analysis, e.g. ENMO (Euclidean Norm Minus One), MAD (Mean Amplitude Deviation), MIMS (Monitor Independent Movement Summary) or Counts. We compared associations with all-cause mortality of the volume and intensity of physical activity when derived from those four measures in the Whitehall II and UK Biobank cohorts. Volume (Average Acceleration, AvAcc) and intensity (Intensity Gradient, IG) were derived from each ESM. Associations with mortality were estimated using Cox models. 3733 (25.1% female, median age 68.3 years) and 89,848 (56.4% female, 63.5 years) participants were included from Whitehall II and UK Biobank, respectively. Median (IQR) follow-up was 11.0 (10.7, 11.3) and 8.0 (7.5, 8.5) years, with 563 (15.1%) and 3656 (4.1%) deaths. Associations with mortality were largely consistent between ESMs with the lowest mortality risk for those high (above the median) in both AvAcc and IG (Whitehall: HR = 0.59-0.68; Biobank: 0.55-0.61, reference: low/low), and IG associated with lower mortality risk, irrespective of AvAcc. AvAcc was associated with lower mortality irrespective of IG in Biobank only. In conclusion, associations of AvAcc and IG with mortality are broadly consistent across common ESMs, supporting comparability of activity-health findings across studies using different ESMs.

Scientific ReportsVol. 16(1)
Office for National Statistics (GB), Baker Heart and Diabetes Institute (AU), Loughborough University (GB), Deakin University (AU), University of Leicester (GB), Inserm (FR), University of South Australia (AU), Glasgow Caledonian University (GB), University of Agder (NO), Université Paris Cité (FR), Leicester General Hospital (GB), Russell Group (GB), University Hospitals of Leicester NHS Trust (GB), Ghent University (BE), Sorbonne Paris Cité (FR), Wellcome/MRC Institute of Metabolic Science (GB), MRC Epidemiology Unit (GB), NIHR Leicester Biomedical Research Centre (GB), Centre de Recherche Épidémiologie et Statistique (FR), University College London (GB)
UK Research and Innovation, Fondation Vaincre Alzheimer, National Institute for Health and Care Research, Department of Health and Social Care, University of Leicester, European Commission, FONDATION ALZHEIMER, HORIZON EUROPE Framework Programme, NIHR Leicester Biomedical Research Centre
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