Exosome-derived Menin from cancer-associated fibroblasts promotes gastric cancer progression by activating the HSPA6/JNK/JunD pathway and inducing EMT
CAFs can promote GC progression by delivering Menin-containing exosomes, which activates the HSPA6/JNK/JunD pathway and induces EMT. Targeting Menin within CAFs and GC cells and blocking the delivery of Menin by exosomes may provide novel strategies for GC treatment.
Authors
- Jun Jiang (ORCID: https://orcid.org/0000-0002-8931-9872)
- Shu-Zheng Wang
- Kaitian Zheng
- Zhen Wang (ORCID: https://orcid.org/0000-0002-8581-4649)
- Tong Chen (ORCID: https://orcid.org/0000-0001-7895-2077)
- Shijie Zhang (ORCID: https://orcid.org/0000-0002-6973-493X)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s12967-025-07539-3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00