Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia
In patients with previously untreated CLL, fixed-duration treatment with venetoclax-obinutuzumab or venetoclax-ibrutinib was noninferior to continuous ibrutinib with regard to investigator-assessed progression-free survival. (Funded by the University of Cologne and others; CLL17 ClinicalTrials.gov number, NCT04608318; EudraCT number, 2019-003854-99.).
Authors
- Mark‐David Levin (ORCID: https://orcid.org/0000-0003-2139-3547)
- Florian Simon (ORCID: https://orcid.org/0000-0002-2700-3717)
- Caspar da Cunha‐Bang (ORCID: https://orcid.org/0000-0002-7800-3098)
- Clemens‐Martin Wendtner (ORCID: https://orcid.org/0000-0003-2866-2260)
- Stephan Stilgenbauer (ORCID: https://orcid.org/0000-0002-6830-9296)
- Vesa Lindström (ORCID: https://orcid.org/0000-0001-5724-9120)
- Sebastian Böttcher (ORCID: https://orcid.org/0000-0002-3603-761X)
- Jeroen S. Goede (ORCID: https://orcid.org/0000-0003-1464-0423)
- Emadoldin Feyzi
- Mattias Mattsson (ORCID: https://orcid.org/0000-0002-9510-8801)
- Tamar Tadmor (ORCID: https://orcid.org/0000-0002-3435-8612)
- Philipp Bernhard Staber (ORCID: https://orcid.org/0000-0001-6729-7708)
- Lydia Scarfò (ORCID: https://orcid.org/0000-0002-0844-0989)
- F. Xavier Bosch (ORCID: https://orcid.org/0000-0002-7172-3412)
- Thomas Noesslinger
- Jan‐Paul Bohn (ORCID: https://orcid.org/0000-0002-2066-7377)
- Marjolein van der Klift (ORCID: https://orcid.org/0000-0003-3333-1327)
- Ohad Benjamini (ORCID: https://orcid.org/0000-0003-1123-3339)
- Anna Sandstedt
- Thomas Illmer
- John Schreurs (ORCID: https://orcid.org/0009-0005-7588-0991)
- Eugen Tausch
- Javier Loscertales (ORCID: https://orcid.org/0000-0003-3561-3758)
- Carsten Utoft Niemann (ORCID: https://orcid.org/0000-0001-9880-5242)
- Ruth Clifford (ORCID: https://orcid.org/0009-0003-8727-2550)
- Kirsten Fischer (ORCID: https://orcid.org/0009-0006-6169-9152)
- Arnon Philip Kater (ORCID: https://orcid.org/0000-0003-3190-1891)
- Sandra Robrecht (ORCID: https://orcid.org/0000-0001-8848-6655)
- Anna Maria Frustaci (ORCID: https://orcid.org/0000-0003-2587-7901)
- Ann Janssens (ORCID: https://orcid.org/0000-0002-1812-412X)
- Anna Maria Fink (ORCID: https://orcid.org/0009-0002-9903-283X)
- Hoa Tran
- Matthias Ritgen (ORCID: https://orcid.org/0000-0002-0957-3804)
- Bjoern Schoettker
- Michael J. Hallek (ORCID: https://orcid.org/0000-0002-7425-4455)
- Patrick D. Thornton (ORCID: https://orcid.org/0000-0002-5126-9590)
- Juha Ranti (ORCID: https://orcid.org/0000-0002-5198-2847)
- Elisabeth Vandenberghe (ORCID: https://orcid.org/0000-0002-7731-9437)
- Janina Stumpf
- Javier de la Serna (ORCID: https://orcid.org/0000-0003-3904-1101)
- Michaël Baumann (ORCID: https://orcid.org/0000-0002-9340-974X)
- Paolo Sportoletti (ORCID: https://orcid.org/0000-0002-5630-9862)
- Oscar Lindblad
- Othman Al‐Sawaf (ORCID: https://orcid.org/0000-0001-9895-0570)
- Paolo Ghia (ORCID: https://orcid.org/0000-0003-3750-7342)
- Christof Schneider (ORCID: https://orcid.org/0000-0001-9719-7345)
- Hanneke van der Straaten
- Can Zhang
- Christian Bo Poulsen (ORCID: https://orcid.org/0000-0002-1361-543X)
- Karl-Anton Kreuzer
- Michael Gregor
- Tobias Gaska
- Barbara Eichhorst
Institutions
- Hebron University (PS)
- University of Helsinki (FI)
- Winterthur Museum Garden and Library (US)
- Uppsala University Hospital (SE)
- Innsbruck Medical University (AT)
- Vita-Salute San Raffaele University (IT)
- University of Lucerne (CH)
- Universität Innsbruck (AT)
- Universität Ulm (DE)
- Trinity College (CA)
- University of Perugia (IT)
- Sheba Medical Center (IL)
- Kantonsspital St. Gallen (CH)
- Akershus University Hospital (NO)
- Universitair Ziekenhuis Leuven (BE)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University Hospital Limerick (IE)
- Zealand University Hospital (DK)
- Winterthur Gas & Diesel (Switzerland) (CH)
- Azienda Ospedaliera di Perugia (IT)
- Düsseldorf University Hospital (DE)
- Albert Schweitzer Ziekenhuis (NL)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Rode Kruis Ziekenhuis (NL)
- Kantonsspital Winterthur (CH)
- Hanusch Hospital (AT)
- Hospital Universitario 12 De Octubre (ES)
- Cancer Trials Ireland (IE)
- St Olav's University Hospital (NO)
- Amphia Ziekenhuis (NL)
- Martini Ziekenhuis (NL)
- University Hospital Schleswig-Holstein (DE)
- Bnai Zion Medical Center (IL)
- Universitäts Hautklinik Kiel (DE)
- Hospital Universitario de La Princesa (ES)
- Brüderkrankenhaus St. Josef Paderborn (DE)
- IRCCS Ospedale San Raffaele (IT)
- Skåne University Hospital (SE)
- Praxis für Hämatologie und Onkologie (DE)
- Hovon (NL)
- Danish Cancer Society (DK)
- Amsterdam University Medical Centers (NL)
- Linköping University Hospital (SE)
- Schmerzklinik Kiel (DE)
- University Hospital Cologne (DE)
- Vall d'Hebron Institute of Oncology (ES)
- Heinrich Heine University Düsseldorf (DE)
- University of Rostock (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- Deutsche Forschungsgemeinschaft (DE)
- Saarland University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1056/nejmoa2515458
- Citations
- 13
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 21.13