MedFact-R1: Towards Factual Medical Reasoning Via Pseudo-Label Augmentation

Ensuring factual consistency and reliable reasoning remains a critical challenge for medical vision-language models. We introduce MedFact-R1, a two-stage framework that integrates external knowledge grounding with reinforcement learning to improve the factual medical reasoning. The first stage uses pseudo-label supervised fine-tuning (SFT) to incorporate external factual expertise; while the second stage applies Group Relative Policy Optimization (GRPO) with four tailored factual reward signals to encourage self-consistent reasoning at deployment time without relying on external RAG. Across three public medical QA benchmarks, MedFact-R1 delivers up to 22.5% absolute improvement in factual accuracy over previous state-of-the-art methods. Ablation studies highlight the necessity of pseudo-label SFT cold start and validate the contribution of each GRPO reward, underscoring the synergy between knowledge grounding and RL-driven reasoning for trustworthy medical AI. Codes are released at https://github.com/Garfieldgengliang/MEDFACT-R1.

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Publication Details

Published
2026-04-21
DOI
https://doi.org/10.1109/icassp55912.2026.11462237
Primary Topic
Multimodal Machine Learning Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

MedFact-R1: Towards Factual Medical Reasoning Via Pseudo-Label Augmentation

Gengliang Li, Bin Li, Linlin Yang, R. S. Chen et al.
Multimodal Machine Learning Applications
article

MedFact-R1: Towards Factual Medical Reasoning Via Pseudo-Label Augmentation

Gengliang Li, Bin Li, Linlin Yang, R. S. Chen, Guodong Ding
article en

Abstract

Ensuring factual consistency and reliable reasoning remains a critical challenge for medical vision-language models. We introduce MedFact-R1, a two-stage framework that integrates external knowledge grounding with reinforcement learning to improve the factual medical reasoning. The first stage uses pseudo-label supervised fine-tuning (SFT) to incorporate external factual expertise; while the second stage applies Group Relative Policy Optimization (GRPO) with four tailored factual reward signals to encourage self-consistent reasoning at deployment time without relying on external RAG. Across three public medical QA benchmarks, MedFact-R1 delivers up to 22.5% absolute improvement in factual accuracy over previous state-of-the-art methods. Ablation studies highlight the necessity of pseudo-label SFT cold start and validate the contribution of each GRPO reward, underscoring the synergy between knowledge grounding and RL-driven reasoning for trustworthy medical AI. Codes are released at https://github.com/Garfieldgengliang/MEDFACT-R1.

HealthInsight (US)
National Natural Science Foundation of China
Openalex Percentile: Top 99%
Multimodal Machine Learning Applications
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