UBC9 mediates mitophagy to attenuate oxidative stress by regulating SUMOylation of PINK1 in the Parkinson’s disease progression
UBC9 mediated mitophagy to attenuate MPP<sup>+</sup>/MPTP-induced neurotoxicity and oxidative stress by regulating PINK1 SUMOylation, suggesting that UBC9 may play a preventive role in PD progression.
Authors
- Junmei Zhang
- Yanjin Wang (ORCID: https://orcid.org/0009-0003-8270-0288)
- Yuxiang Cai (ORCID: https://orcid.org/0000-0002-1344-2858)
- Jian Liu (ORCID: https://orcid.org/0000-0002-3220-1240)
- Yu Zhou (ORCID: https://orcid.org/0000-0003-2339-7568)
- Ge Jia
Institutions
- Central South University (CN)
- Jiangxi Chest Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1007/s10565-025-10126-3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00