Montelukast as a novel therapeutic approach in metastatic uveal melanoma harboring a CYSLTR2 mutation: a translational case report
This is the first published case suggesting a potential role for leukotriene receptor antagonists in CYSLTR2-mutant UM. These findings support further preclinical and clinical investigation of montelukast as a repurposed therapy in this challenging disease entity.
Authors
- Cindy Franklin (ORCID: https://orcid.org/0000-0001-9142-5423)
- Nicole Kreuzberg
- Matthias Scheffler (ORCID: https://orcid.org/0000-0002-9031-1368)
- Udo Siebolts (ORCID: https://orcid.org/0000-0002-7463-9195)
- Simon Lennartz (ORCID: https://orcid.org/0000-0002-3254-4809)
- A Gläser
- Christina Langhorst
- Philipp Koll
- D Smarsly
Institutions
- Düsseldorf University Hospital (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105921
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00