Mediation of Polygenic Asthma Risk Through Gene Expression
We found the best PRS to be the one derived using the largest sample size and including African-ancestry individuals. Mediation supports the well-documented biology of T2 inflammation in asthma as well as pathophysiological components of asthma like wound healing and medication response.
Authors
- Nadia N. Hansel (ORCID: https://orcid.org/0000-0002-8740-9751)
- H L Watson
- Margaret A. Taub (ORCID: https://orcid.org/0000-0001-8008-618X)
- Kathleen C. Barnes (ORCID: https://orcid.org/0000-0002-3030-4705)
- Carole Ober (ORCID: https://orcid.org/0000-0003-4626-9809)
- Camila Alexandrina Figueiredo (ORCID: https://orcid.org/0000-0003-1356-6188)
- Genevieve L. Wojcik (ORCID: https://orcid.org/0000-0001-7206-8088)
- Rama Natarajan (ORCID: https://orcid.org/0000-0003-4494-1788)
- Eimear E. Kenny (ORCID: https://orcid.org/0000-0001-9198-759X)
- Randi K. Johnson (ORCID: https://orcid.org/0000-0001-9345-4439)
- Brooke Szczesny
- Edward T. Naureckas (ORCID: https://orcid.org/0000-0002-3171-8176)
- Álvaro Augusto Cruz (ORCID: https://orcid.org/0000-0002-7403-3871)
- Kanika Kanchan (ORCID: https://orcid.org/0009-0003-4993-8841)
- Wendy Lorizio
- Rasika A. Mathias (ORCID: https://orcid.org/0000-0002-2282-9042)
- R. Clive Landis (ORCID: https://orcid.org/0000-0002-5835-7876)
- Charles N. Rotimi (ORCID: https://orcid.org/0000-0001-5759-053X)
- Andrew H. Liu (ORCID: https://orcid.org/0009-0004-3961-869X)
- Ingo Ruczinski (ORCID: https://orcid.org/0000-0003-3278-6274)
- Christopher O. Olopade (ORCID: https://orcid.org/0000-0002-4243-1488)
- Sameer Chavan (ORCID: https://orcid.org/0000-0002-0220-0845)
- Ayo P. Doumatey (ORCID: https://orcid.org/0000-0001-9494-7710)
- Meher Preethi Boorgula
- Monica Campbell
- Olumide M. Sogaolu
- Ganiyu Arinola
- Adegoke G. Falade
- B. Louise Giles
- Erika Esquinca
Institutions
- Universidade Federal da Bahia (BR)
- National Institutes of Health (US)
- Fundação de Amparo à Pesquisa do Estado da Bahia (BR)
- Universidade do Estado da Bahia (BR)
- Mount Sinai Health System (US)
- Johns Hopkins University (US)
- Colorado School of Public Health (US)
- University of Ibadan (NG)
- Johns Hopkins Medicine (US)
- University College Hospital, Ibadan (NG)
- University of Chicago (US)
- National Human Genome Research Institute (US)
- Children's Hospital Colorado (US)
- National Institute of Allergy and Infectious Diseases (US)
- University of the West Indies (BB)
- Queen Elizabeth Hospital (BB)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1111/all.70101
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research