Direct α-halogenation of carboxylic acids with <i>N</i> -bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H <sub>2</sub> SO <sub>4</sub>
α-Halogenation of carboxylic acids with <i>N</i>-bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H<sub>2</sub>SO<sub>4</sub> in 1,2-dichloroethane was devised. The method does not need prior conversion to acyl chlorides, and the reactions could be applied to a gram-scale synthesis.
Authors
- Kiyoshi Tanemura (ORCID: https://orcid.org/0009-0002-3368-806X)
Institutions
- Nippon Dental University (JP)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1039/d5ob01483b
- Citations
- 1
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.54