Lung infection in orally inoculated SARS-CoV-2 hamsters
The digestive tropism of SARS-CoV-2 due to the presence of the same ACE2 receptor in the digestive system as in the respiratory system raised the question of the role of fecal-oral transmission in the pandemic. The aim of this study was to explore oral infection in hamsters model. SARS-CoV-2 inoculation via the oral and intranasal routes resulted in comparable infection in hamsters. In addition to implications for human health, oral infection could have implications for potential animal reservoirs.
Authors
- Evelyne Picard‐Meyer (ORCID: https://orcid.org/0000-0001-9122-9027)
- Edgar Torres-Maravilla (ORCID: https://orcid.org/0000-0002-3359-4517)
- Élodie Monchâtre-Leroy (ORCID: https://orcid.org/0000-0002-3231-398X)
- Marine Wasniewski (ORCID: https://orcid.org/0000-0001-5054-3634)
- Alexandre Servat (ORCID: https://orcid.org/0000-0003-4753-6614)
- Elsa Jacouton
- Thibaut Larcher (ORCID: https://orcid.org/0000-0002-0396-3190)
- Anne‐Judith Waligora‐Dupriet (ORCID: https://orcid.org/0000-0002-4885-5302)
- Philippe Langella (ORCID: https://orcid.org/0000-0001-5960-4341)
- Sophie Holowacz (ORCID: https://orcid.org/0000-0002-1344-6867)
- Franck Boué (ORCID: https://orcid.org/0000-0003-0957-1320)
- Vinciane Saint‐Criq (ORCID: https://orcid.org/0000-0003-0042-3735)
- Kevyn Beissat
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Sorbonne Paris Cité (FR)
- VetAgro Sup (FR)
- Life Services (United States) (US)
- Fédération Internationale de l'Automobile (FR)
- Oniris (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0337915
- Primary Topic
- Dental Research and COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00