Adaptability of lung and liver metastatic breast cancer cells to glucose
Our findings reveal that metM-Wnt<sup>Lung</sup> cells exhibit greater metabolic flexibility to glucose than metM-Wnt<sup>Liver</sup> cells by shifting from glycolysis to oxidative phosphorylation under high glucose conditions while utilizing gluconeogenesis and glutamine under glucose deprivation conditions.
Authors
- Marjorie Anne Layosa (ORCID: https://orcid.org/0000-0001-5080-0127)
- Chaylen Andolino (ORCID: https://orcid.org/0000-0001-6836-049X)
- Dorothy Teegarden (ORCID: https://orcid.org/0000-0002-7045-3748)
- Stephen David Hursting (ORCID: https://orcid.org/0000-0003-3605-2833)
- Madeline P. Sheeley (ORCID: https://orcid.org/0000-0002-5102-0533)
- Michael K. Wendt (ORCID: https://orcid.org/0000-0002-3665-7413)
- Alekya Raghavan
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s12935-025-04006-3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health