Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases
This meta-analysis investigates the association between the p53 rs1042522 polymorphism and thyroid cancer, analyzing 18 case-control studies with 2,116 cases and 4,017 controls. It finds that the C allele is linked to a higher cancer risk (OR 1.572, 95% CI: 1.062-2.326, p = 0.024) but shows significant heterogeneity (I<sup>2</sup> = 94.15%). Subgroup analyses indicate protective effects in Caucasian, Asian, and mixed populations (ORs around 0.008 to 0.011). Notably, Follicular and Differentiated Thyroid Carcinomas show strong protective associations, suggesting that while the C allele may increase risk, certain populations may experience reduced risk, emphasizing genetic complexity.
Authors
- Seyed Masoud HaghighiKian (ORCID: https://orcid.org/0000-0003-4674-5764)
- Maryam Aghasipour (ORCID: https://orcid.org/0009-0003-8774-3172)
- Hossein Neámatzadeh (ORCID: https://orcid.org/0000-0003-1031-9288)
- Maedeh Barahman (ORCID: https://orcid.org/0000-0003-0660-0069)
- Ahmad Shirinzadeh-Dastgiri (ORCID: https://orcid.org/0009-0005-2152-5425)
- Abolhasan Alijanpour (ORCID: https://orcid.org/0000-0002-8053-1594)
- Kazem Aghili (ORCID: https://orcid.org/0009-0007-3226-5571)
- Amirhossein Rahmani (ORCID: https://orcid.org/0000-0002-1771-3053)
- Mohammad Vakili-Ojarood (ORCID: https://orcid.org/0000-0002-4396-5828)
- Mojtaba Meybodian (ORCID: https://orcid.org/0000-0003-0658-7757)
- Amirhosein Naseri (ORCID: https://orcid.org/0000-0001-8548-1330)
- Mehdi Khosravi-Mashizi
Institutions
- Iran University of Medical Sciences (IR)
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Ardabil University of Medical Sciences (IR)
- Rasool Akram Hospital (IR)
- Firoozgar General Hospital (IR)
- Iranshahr University (IR)
- Sina Hospital (IR)
- Imam Reza Hospital (IR)
- Day General Hospital (IR)
- Babol University of Medical Sciences (IR)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1080/07357907.2025.2596853
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00