NIR-II photozymes with stoichiometric chemistry-regulated enzyocatalytic activities for multi-modal nanocatalytic therapy

Nanocatalytic therapy faces limitations from low ROS efficiency and high intracellular GSH. We develop trigonal PtTe₂ photozymes (t-PtTe₂) with stoichiometry-regulated multi-enzymatic (POD-, CAT-, OXD-like) and NIR-II responses. In acidic tumors, t-PtTe₂ generates ˙OH (POD-like), produces O₂ (CAT-like), and depletes GSH to amplify ROS. Under NIR-II, it enhances efficacy <i>via</i> photothermal effect and ¹O₂ photodynamic generation, synergizing with enzyme-catalyzed ROS to induce robust tumor apoptosis with minimal systemic toxicity.