Expanded blood PD-1hi Tfh cells in seropositive clinically suspect arthralgia predict progression to rheumatoid arthritis
Seropositive CSA patients display elevated baseline cTfh and cTph frequencies. Higher cTfh proportions associate with progression to RA. These findings support the use of cTfh and cTph profiling to stratify progression risk and guide early therapeutic decisions in at-risk individuals.
Authors
- María‐Eugenia Miranda‐Carús (ORCID: https://orcid.org/0000-0002-2334-4733)
- Marta Novella-Navarro (ORCID: https://orcid.org/0000-0002-2200-0859)
- Diana Peiteado (ORCID: https://orcid.org/0000-0002-6953-409X)
- I. Monjo (ORCID: https://orcid.org/0000-0002-3252-8016)
- Eugenio de Miguel (ORCID: https://orcid.org/0000-0001-5146-1964)
- Beatriz Nieto-Carvalhal (ORCID: https://orcid.org/0009-0002-9913-9266)
- Laura Nuño (ORCID: https://orcid.org/0000-0001-7152-0458)
- Alejandro Villalba
- Mariana Gutiérrez-Riart
Institutions
- Hospital Universitario La Paz (ES)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1093/rheumatology/keaf648
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00