Cannabidiol reduces LPS-induced inflammatory response in the human placenta by reducing NF-κB translocation
CBD exerts anti-inflammatory effects in human placenta and trophoblasts, associated with reduced NF-κB p65 nuclear translocation and independent of CB1, CB2, and TRPV1 signaling, without evidence of canonical inflammasome activation. Given the placenta's role in fetal programming, these findings underscore the importance of evaluating CBD's developmental impact in the context of its growing perinatal use.
Authors
- Mohammad Ghaddar
- Cilia Abad (ORCID: https://orcid.org/0000-0001-9951-7242)
- Tetiana Synova
- Rona Karahoda (ORCID: https://orcid.org/0000-0003-1962-0288)
- Miloslav Macháček (ORCID: https://orcid.org/0000-0001-7221-5914)
- Ramón Portillo (ORCID: https://orcid.org/0000-0001-6453-8617)
- František Štaud (ORCID: https://orcid.org/0000-0001-6712-097X)
- Fiona Kumnova
- Mia Salma Alsouki
Institutions
- Charles University (CZ)
- University Hospital Hradec Králové (CZ)
- University of Hradec Králové (CZ)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s42238-025-00369-6
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00