Diagnostic challenges of the neurofibroma–malignant peripheral nerve sheath tumor spectrum in neurofibromatosis type 1: illustrative case
This case underscores the difficulty in distinguishing ANNUBP from MPNSTs. Accurate diagnosis is crucial for guiding appropriate treatment, improving patient survival, and reducing the risk of recurrence. Improved molecular and imaging techniques are needed to optimize early detection and treatment strategies for MPNSTs in NF-1 patients. https://thejns.org/doi/10.3171/CASE25580.
Authors
- Brandon T. Lee (ORCID: https://orcid.org/0009-0007-3266-4302)
- H. Benjamin (ORCID: https://orcid.org/0000-0002-1435-8455)
- Timothy Murray (ORCID: https://orcid.org/0000-0003-2027-8053)
- Mark Attiah (ORCID: https://orcid.org/0000-0001-8609-7883)
- Andrew Abumoussa
- Jan F. Silverman (ORCID: https://orcid.org/0009-0002-4887-6821)
- Lauren E. Corliss
- Zoe Robinow (ORCID: https://orcid.org/0009-0001-1767-2052)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of North Carolina Hospitals (US)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3171/case25580
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00