Opioid Hypermetabolism in a Multiextremity Spine Trauma Patient
Genetic mutations in CYP2D6 can result in impaired opioid metabolism and impaired pain control. Impaired pain control in musculoskeletal trauma patients should raise concern for a potential CYP2D6 mutation. A proper understanding of this condition and adjustments in pain management can guide optimal care for these patients.
Authors
- John T. Anderson (ORCID: https://orcid.org/0000-0002-2866-1500)
- Kenneth Aaron Shaw (ORCID: https://orcid.org/0000-0002-3553-2889)
- Anne Stuedemann (ORCID: https://orcid.org/0009-0007-1365-2488)
- Nicolette Saddler (ORCID: https://orcid.org/0009-0000-1638-1037)
- Zach Denton (ORCID: https://orcid.org/0009-0006-5862-6243)
- Stephen Fanous
Institutions
- Children's Mercy Hospital (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- JBJS Case Connector
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2106/jbjs.cc.25.00430
- Citations
- 1
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 2.19