Dissecting definitions of disability accrual in relapsing multiple sclerosis—Have we reached standardization yet?
PIRA predominantly drives disability accrual, yet definitional variation substantially influenced event rates and RAW/PIRA proportions. Transparent reporting and further optimization of definitions are critical for improving comparability, interpretation, and clinical relevance in MS research and care.
Authors
- Franziska Di Pauli (ORCID: https://orcid.org/0000-0001-6183-2394)
- Harald Hegen
- Christian Enzinger (ORCID: https://orcid.org/0000-0001-9764-7617)
- Jörg Kraus (ORCID: https://orcid.org/0000-0002-3637-611X)
- Gabriel Bsteh (ORCID: https://orcid.org/0000-0002-0825-0851)
- Michael Guger (ORCID: https://orcid.org/0000-0001-8219-781X)
- Stefanie Marti (ORCID: https://orcid.org/0000-0001-8237-6965)
- Robert Hoepner (ORCID: https://orcid.org/0000-0002-0115-7021)
- Nik Krajnc (ORCID: https://orcid.org/0000-0002-4146-5870)
- Thomas Berger (ORCID: https://orcid.org/0000-0001-5626-1144)
- Andrew Chan
- Helly Hammer (ORCID: https://orcid.org/0000-0003-3486-3448)
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Medical University of Graz (AT)
- University Hospital of Bern (CH)
- Salzburger Landeskliniken (AT)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1177/13524585251396283
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00