Small-molecule therapies for pediatric inflammatory bowel disease: toward precision medicine
Small-molecule therapies offer a promising and mechanistically precise direction for the management of pIBD. Future progress will depend on age-specific clinical trials, physiologically based pharmacokinetic modeling, and biomarker discovery through integrated multiomics. Collaborative multicenter research is essential to optimize the safety and efficacy of these agents in children.
Authors
- Jing Guo (ORCID: https://orcid.org/0000-0003-3689-6374)
- Ying Chen (ORCID: https://orcid.org/0000-0001-9086-2832)
- Yang Wang (ORCID: https://orcid.org/0000-0002-5276-7081)
- Xu Teng (ORCID: https://orcid.org/0000-0002-0566-5859)
- Lingfen Xu (ORCID: https://orcid.org/0000-0002-2855-7551)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- World Journal of Pediatrics
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1007/s12519-025-01001-6
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China