Deficiency of Kdm1a Induces Locomotor Abnormalities and Learning and Memory Deficits in Zebrafish Larvae
These results indicated that <i>kdm1a</i> deficiency induced locomotor abnormalities and learning and memory deficits in zebrafish larvae accompanied by activation of autophagy and apoptosis. These findings indicate a key role of <i>kdm1a</i> in neurodevelopment, providing novel insights into the mechanisms underlying the neurodevelopmental disorders.
Authors
- Xia Chi (ORCID: https://orcid.org/0000-0002-7439-0000)
- Li Zou (ORCID: https://orcid.org/0009-0008-1843-7960)
- Jingyu Wang (ORCID: https://orcid.org/0009-0005-6015-011X)
- Qin Hong (ORCID: https://orcid.org/0000-0001-6183-105X)
- Jiansheng Zhu (ORCID: https://orcid.org/0000-0002-2215-3927)
- Qu Xu (ORCID: https://orcid.org/0009-0000-2688-9811)
- M. Yao (ORCID: https://orcid.org/0009-0006-9292-8288)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-11-25
- DOI
- https://doi.org/10.31083/jin44394
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province