A Novel Long-Term Intrathecal Cannulation Technique in Rats: L5-L6 Approach With Cervical Externalization for Chronic Drug Delivery
Our L5-L6 approach effectively minimized the risk of spinal cord injury. The choice of PTFE material proved crucial, as it enabled 100% long-term patency, a result not achieved with other materials. Combined with the neck-mounted external design, this technique offers an improved approach for repeated IT drug delivery in rat models, but more studies are needed to confirm its effectiveness in a wider range of pharmacological applications.
Authors
- Yanchao Ma (ORCID: https://orcid.org/0000-0003-2091-0696)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-7021-5395)
- Wenming Zhou (ORCID: https://orcid.org/0000-0001-5201-8833)
- Guanghai Zhao
- Zhang Hai-hong (ORCID: https://orcid.org/0009-0002-9373-8137)
- Nan Wei (ORCID: https://orcid.org/0000-0001-6019-0633)
- Yanbo Dong (ORCID: https://orcid.org/0000-0003-4682-5537)
- Yongqiang Shi
- Rui Ran
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-11-21
- DOI
- https://doi.org/10.31083/jin45111
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article
- Field-Weighted Citation Impact
- 0.00