The Role of the Hippocampal P2X7R/NLRP3 Signaling Pathway in Depression-Like Behavior Induced by the Interaction Between Chronic Stress and Time in a Rat Model of Stroke
These findings are consistent with the involvement of P2X7R/NLRP3 signaling in hippocampal impairment and inflammation/immune dysregulation in the context of depression-like behaviors induced by CUMS. In particular, behavioral scores may be affected by the interaction between CUMS exposure and time.
Authors
- Wenyan Tang (ORCID: https://orcid.org/0000-0003-4250-9967)
- Xi Tao (ORCID: https://orcid.org/0000-0001-9606-6140)
- Siyuan Wu (ORCID: https://orcid.org/0000-0001-9842-7237)
- Yifan Yin (ORCID: https://orcid.org/0009-0005-4034-2835)
- Juan He (ORCID: https://orcid.org/0000-0002-2316-6682)
- Chen Yang (ORCID: https://orcid.org/0009-0006-8179-6072)
- Yu Zhang (ORCID: https://orcid.org/0009-0005-6052-7087)
Institutions
- Hunan Normal University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- Hunan Mawangdui Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Hunan Provincial People's Hospital (CN)
- Department of Science and Technology of Hunan Province (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-11-11
- DOI
- https://doi.org/10.31083/jin40005
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province