Reversible Evolution of Ceftazidime-Avibactam Resistance Driven by blaKPC-71 and Aerobactin Loss in ST11-KL64 Hypervirulent Klebsiella Pneumoniae
This study provides the first clinical evidence of the reversible in vivo evolution of an insertional KPC-71 variant under antibiotic pressure. The findings reveal a dynamic balance between resistance and virulence mediated by <i>bla</i> <sub>KPC</sub> mutations and plasmid remodeling, highlighting the risk of resistance cycling during CZA treatment and the need for genomic surveillance in managing CRKP infections.
Authors
- Qingsong Tao (ORCID: https://orcid.org/0000-0002-3936-6005)
- Zhenlei Xiao
- Si Xu
- Zhenghai Yang (ORCID: https://orcid.org/0009-0001-7586-1425)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s565339
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59