Distinct gut microbiota signatures and metabolic dysregulation in individuals with type 1 diabetes: insights into a microbiome-metabolite axis
Our study reveals profound structural and functional alterations in the gut microbiome of individuals with T1D. These findings support the existence of a gut microbial-metabolite axis in autoimmune diabetes and suggest that microbial biomarkers and metabolic pathways may serve as novel targets for early diagnosis and therapeutic intervention. Longitudinal studies are warranted to validate these signatures and explore microbiota-based therapies for T1D prevention and management.
Authors
- Abdullah F. Aldairi (ORCID: https://orcid.org/0000-0003-2861-6299)
- Abdulhadi Bima (ORCID: https://orcid.org/0000-0002-5401-1106)
- Mohd Wahid (ORCID: https://orcid.org/0000-0001-7068-8769)
- Ahmad O. Babalghith (ORCID: https://orcid.org/0000-0001-6650-9158)
- Farkad Bantun (ORCID: https://orcid.org/0000-0002-7851-6977)
- Shafiul Haque (ORCID: https://orcid.org/0000-0002-2989-121X)
- Naif A. Jalal (ORCID: https://orcid.org/0000-0002-3866-1010)
- Faraz Ahmad (ORCID: https://orcid.org/0000-0003-4284-8045)
Institutions
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- Universidad Espíritu Santo (EC)
- Vellore Institute of Technology University (IN)
- Jazan University (SA)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s13099-025-00779-0
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00