Preventive Effect of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium in Elderly Patients with Sleep Disorders Undergoing Major Noncardiac Surgery: A Randomized, Triple-Blind, Placebo-Controlled Trial
Preoperative intranasal dexmedetomidine reduced the incidence of POD and enhanced preoperative sleep quality in elderly patients with sleep disorders undergoing major noncardiac surgery. Given the increased risk of bradycardia, these benefits should be weighed against the need for perioperative monitoring.
Authors
- Shengfeng Yang
- Jing Shi (ORCID: https://orcid.org/0000-0002-9687-8592)
- Yewei Shi
- Chao Chen (ORCID: https://orcid.org/0000-0001-7374-8755)
- Jun Lu (ORCID: https://orcid.org/0000-0002-5618-8167)
- Xinglong Xiong
- Sijie Tang (ORCID: https://orcid.org/0000-0001-6588-1855)
- Ruixue Zhai
- Dongxu Chen (ORCID: https://orcid.org/0000-0002-1414-3163)
- Zhan-ming Zhu (ORCID: https://orcid.org/0009-0006-9365-3028)
- Guangling Tang
Institutions
- Guiyang Medical University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s559012
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Guizhou Medical University