The impact of initiating SGLT2 inhibitors on eGFR: a pilot study at a secondary hospital in Malaysia

A total of 76 patients were included. Serum creatinine showed a mild rise at three months after treatment initiation and subsequently stabilised at six and twelve months. Estimated glomerular filtration rate declined over one year, but the reduction was modest and remained below ten per cent. Blood glucose control improved, with mean glycated haemoglobin decreasing from baseline to the three-month assessment and remaining stable thereafter. No meaningful association was observed between changes in glycated haemoglobin and kidney function throughout the follow-up period. Overall, the findings indicate that kidney function stabilised after the early phase of treatment and that blood glucose levels improved following the introduction of sodium-glucose cotransporter 2 inhibitors.