Sodium Alginate Microgel-Wrapped Primary Human Peritoneal Mesothelial Cells for the Treatment of Peritoneal Fibrosis Caused by Dialysis via the POSTN/NF-κB/CXCL8 Pathway
Consistent results from <i>in vivo</i> and <i>in vitro</i> models demonstrated that PD and hyperglycemic conditions upregulated the expression of POSTN, NF-κB p65, CXCL8, and profibrotic markers, leading to peritoneal thickening and fibrotic progression. Treatment with SA/PMC microgels ameliorated these effects. By modulating the POSTN/NF-κB/CXCL8 pathway and enhancing PMCs survival, SA/PMC microgels may have therapeutic potential in mitigating peritoneal fibrosis in PD patients.
Authors
- Chunyan Qiu
- Yangping Shentu (ORCID: https://orcid.org/0009-0001-6171-0490)
- Yaozhe Ying (ORCID: https://orcid.org/0009-0008-4383-8774)
- Yongheng Bai (ORCID: https://orcid.org/0000-0003-3910-4731)
- Chunwu Zhang (ORCID: https://orcid.org/0000-0002-4162-0738)
- Shuqing Ma (ORCID: https://orcid.org/0009-0000-9581-8216)
- Luhui Wang (ORCID: https://orcid.org/0000-0003-2253-8234)
- Yunting Wang (ORCID: https://orcid.org/0000-0001-6190-4351)
- Xiao Yang (ORCID: https://orcid.org/0000-0002-0850-7813)
- Chaosheng Chen
- Changcan Shi (ORCID: https://orcid.org/0000-0001-7890-9626)
- Jue Zhang
- Ying Zhou (ORCID: https://orcid.org/0000-0002-3336-5757)
- Chenfei Zheng (ORCID: https://orcid.org/0009-0005-7154-7526)
- Zhe Lin (ORCID: https://orcid.org/0000-0003-1154-9907)
- Ke Zhang (ORCID: https://orcid.org/0009-0005-3248-8279)
Institutions
- Wenzhou University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Wenzhou City People's Hospital (CN)
- University of Houston (US)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-11-27
- DOI
- https://doi.org/10.31083/fbl45614
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00