Integration of Meta-Analysis and Network Pharmacology to Investigate the Pharmacological Mechanisms of Quercetin on Hepatocellular Carcinoma
Preclinically, QT effectively inhibited HCC growth and reduced mortality in tumor-bearing mice without affecting body weight, likely via the PI3K/AKT pathway (targeting AKT1). Our study results furnish preliminary evidence for QT as a promising candidate for HCC adjuvant treatment, supporting its further evaluation in clinical trials. Limitations include reliance on preclinical data; thus, the translational value needs clinical validation, and the underlying mechanisms require more in-depth investigation.
Authors
- Bo Sun (ORCID: https://orcid.org/0000-0002-3217-0579)
- Xu Chen (ORCID: https://orcid.org/0000-0003-3743-5043)
- Jia Zhou (ORCID: https://orcid.org/0000-0002-2811-1090)
- Chuang Peng (ORCID: https://orcid.org/0000-0002-3701-1737)
- Ou Li (ORCID: https://orcid.org/0000-0001-8767-1322)
- Yufan Zhou (ORCID: https://orcid.org/0000-0002-8385-433X)
- You Tang (ORCID: https://orcid.org/0000-0002-6524-6111)
- Yu Chen (ORCID: https://orcid.org/0009-0000-0367-4965)
- Zhiguo Tan (ORCID: https://orcid.org/0009-0001-7318-5910)
- Yuhuai Peng
Institutions
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-11-27
- DOI
- https://doi.org/10.31083/fbl46289
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81