Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells
Sch B enhances TMZ-induced cytotoxicity in U87 glioma cells by promoting mitochondrial dysfunction, oxidative stress, and caspase-mediated apoptosis. These findings suggest that Sch B may serve as a promising adjuvant to improve the efficacy of TMZ-based glioma therapy, warranting further validation in resistant and <i>in-vivo</i> models.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8693-3060)
- Cun-Yang Guo (ORCID: https://orcid.org/0009-0004-5439-6546)
- Han Liu (ORCID: https://orcid.org/0000-0002-2639-5755)
- Hong Jin
- Yuan Dong (ORCID: https://orcid.org/0000-0001-6579-6466)
- Jianxin Liu (ORCID: https://orcid.org/0000-0002-9630-4011)
- Xiangyu Ma (ORCID: https://orcid.org/0009-0001-1352-4968)
- Na Wen (ORCID: https://orcid.org/0000-0001-5439-0444)
- Zebo Tang
Institutions
- Jilin Medical University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-11-27
- DOI
- https://doi.org/10.31083/fbl46410
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00