P110 Inhibits DRP1/FIS1-Mediated Mitochondrial Fission to Alleviate Uric Acid–Induced Apoptosis in HK-2 Cells
The overactivation of DRP1 is crucial for UA-induced renal tubular epithelial cell injury. P110 exerts a cytoprotective effect by inhibiting the DRP1/FIS1 interaction and modulating the mitochondrial apoptotic pathway. This study proposes a possible target for therapeutic intervention in the treatment of hyperuricemic nephropathy.
Authors
- Zhigang Ma (ORCID: https://orcid.org/0000-0002-1436-920X)
- Pan Fulin (ORCID: https://orcid.org/0009-0000-9473-8468)
- Canling Long (ORCID: https://orcid.org/0009-0005-2661-2405)
- Yu Liu (ORCID: https://orcid.org/0000-0002-9295-8384)
- Jia Liu (ORCID: https://orcid.org/0000-0003-0909-7710)
- Geng Huang (ORCID: https://orcid.org/0009-0003-7994-7239)
- Yanju Shen (ORCID: https://orcid.org/0009-0006-7458-4397)
Institutions
- Longgang Central Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-11-26
- DOI
- https://doi.org/10.31083/fbl46700
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43