HMGA1/SMAD3 Promoter Complex Mediates PD-L1-Dependent Transcriptional Regulation of GAS6, EGR1 and PD-L1
Our study provides initial evidence that PD-L1 might form HMGA1- and SMAD3-dependent complexes to bind the GAS6, EGR1 and CD274 promoters, thus modulating the transcription of GAS6, EGR1 and PD-L1 mRNA in cancer and sarcoma cells.
Authors
- Hui Guo (ORCID: https://orcid.org/0009-0000-0091-1312)
- Wei Liu (ORCID: https://orcid.org/0000-0002-3095-0221)
- Pingping Tan (ORCID: https://orcid.org/0009-0006-5027-7747)
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-11-20
- DOI
- https://doi.org/10.31083/fbl46743
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00