Oligodendrocyte Inclusion Pathology in Fragile X‐Associated Tremor/Ataxia Syndrome
These findings implicate oligodendrocyte dysfunction in FXTAS pathogenesis which may contribute to demyelination and white matter degeneration. Our data emphasize the need to consider cell type-specific mechanisms in FXTAS and support future therapeutic efforts aimed at restoring glial proteostasis. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Yingratana McLennan (ORCID: https://orcid.org/0000-0001-8272-2012)
- Forrest J. McKenzie (ORCID: https://orcid.org/0000-0003-0890-0321)
- Brett D. Dufour (ORCID: https://orcid.org/0000-0001-9370-6149)
- Verónica Martínez‐Cerdeño (ORCID: https://orcid.org/0000-0002-9613-3603)
- Paul J. Hagerman (ORCID: https://orcid.org/0000-0003-1142-5680)
- Lina Vanessa Becerra-Hernández (ORCID: https://orcid.org/0000-0002-4468-6716)
- Randi J. Hagerman (ORCID: https://orcid.org/0000-0001-5029-8448)
- A Escobar (ORCID: https://orcid.org/0009-0002-3345-671X)
- Flora Tassone
- Hassan Aliashrafzadeh
- Faith Zirkelbach‐Ngai
Institutions
- Shriners Hospitals for Children - Erie (US)
- Pontificia Universidad Javeriana (CO)
- Clínica Girona (ES)
- Shriners Hospitals for Children - Northern California (US)
- Hospital Quirónsalud Barcelona (ES)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
- Universidad del Valle (CO)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1002/mds.70145
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00