Infection with Helicobacter pylori and the age at onset of coeliac disease in the “HUNT4” survey

H. pylori + participants had a mean age of 62.3 years, compared to 54.8 years for negative participants. In those with previously undiagnosed CeD (n = 43), higher antibody levels against GroEL were associated with an older age at sampling (67.2 years for GroEL-positive vs. 50.8 years for negative). Smaller age differences were noted for gGT (6.0 years), UreA (8.6 years), and HpcC (6.4 years), while vacA and cagA showed only minor differences. Participants with CeD and H. pylori + were older than those who were H. pylori-. The presence of antigens such as GroEL, gGT, and UreA appeared to be associated with this age difference. Aside from H. pylori infection in childhood, a cohort effect of H. pylori infection may partly explain the differences.