Chronic alcohol and liver health: The gut-liver axis as a therapeutic target

Chronic alcohol use has a substantial effect on liver health and general morbidity, making it one of the world's main causes of liver disease. Recent studies highlight the pivotal role of the gut-liver axis in the onset and progression of liver disorders linked to alcohol consumption. This review explores the molecular insights of chronic liver damage caused by alcohol, with a focus on the gut-liver axis that includes microbial translocation, increased intestinal permeability, and alcohol-induced dysbiosis. It also looks at how prolonged alcohol use alter the liver metabolism, which accelerate the course of the illness. The study also covers microbiome therapeutic approaches, that attempt to modify the gut microbiome and liver function. This review takes into account the results from clinical trials and animal models to provide a thorough picture of the therapeutic promise and difficulties in this area. These findings provide a basis for further investigation and treatment approaches aimed at lessening the chronic effects of long-term alcohol use on liver function.