Sex hormones influence ORMDL3 expression: Implications for sex-associated asthma phenotype
This study identifies ORMDL3 as an estrogen-responsive regulator of airway responsiveness that may contribute to sex-related differences in asthma features through modulation of sphingolipid metabolism.
Authors
- Martina Simonelli (ORCID: https://orcid.org/0000-0002-0185-4281)
- Joshua Malo (ORCID: https://orcid.org/0000-0003-0644-7754)
- Giuseppe Cirino (ORCID: https://orcid.org/0000-0003-3954-4083)
- Danilo D’Avino (ORCID: https://orcid.org/0000-0002-6350-5191)
- Giuseppina Ferraro
- Antonietta Rossi (ORCID: https://orcid.org/0000-0002-3237-2584)
- Francesca Polverino (ORCID: https://orcid.org/0000-0001-9686-5698)
- Maria Chiara Monti (ORCID: https://orcid.org/0000-0002-1337-2909)
- Maria Antonietta Riemma (ORCID: https://orcid.org/0000-0002-2396-4393)
- Barbara Romano (ORCID: https://orcid.org/0000-0003-2772-5231)
- Ida Cerqua (ORCID: https://orcid.org/0000-0002-4363-7728)
- Maria Francesca Nanì (ORCID: https://orcid.org/0000-0003-1462-3543)
- Elisabetta Granato (ORCID: https://orcid.org/0000-0002-7207-5832)
- Fiorentina Roviezzo (ORCID: https://orcid.org/0000-0003-1582-7396)
- Bruno D’Agostino (ORCID: https://orcid.org/0000-0002-7220-7962)
Institutions
- University of Arizona (US)
- Baylor College of Medicine (US)
- University of Campania "Luigi Vanvitelli" (IT)
- Federico II University Hospital (IT)
- Banner - University Medical Center Tucson (US)
- University of Campania "Luigi Vanvitelli" (IT)
- Pulmonary and Critical Care Associates (US)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.jaci.2025.10.035
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81