Does spontaneous cartilage thickening occur in osteoarthritic knees? Data from IMI-APPROACH and the OAI
Spontaneous cartilage thickening occurs in a relevant proportion of knees with or at risk of knee OA. This intrinsic thickening warrants further investigation into the mechanisms and clinical relevance.
Authors
- I.K. Haugen
- Francisco Javier Blanco (ORCID: https://orcid.org/0000-0001-9821-7635)
- F. Berenbaum
- Mylène P. Jansen (ORCID: https://orcid.org/0000-0003-1929-6350)
- W. Wirth (ORCID: https://orcid.org/0000-0002-2297-8283)
- M. Kloppenburg
- Christoph Salzlechner (ORCID: https://orcid.org/0000-0002-1124-513X)
- S.C. Mastbergen
Institutions
- Inserm (FR)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Diakonhjemmet Hospital (NO)
- Imagineering (Japan) (JP)
- Chondrometrics (Germany) (DE)
- Centre de Recherche Saint-Antoine (FR)
- Instituto de Investigación Biomédica de A Coruña (ES)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.joca.2025.12.002
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Celgene
- Novartis Pharmaceuticals Corporation
- CSL Behring
- Merck KGaA
- Zoetis
- European Federation of Pharmaceutical Industries and Associations
- Boehringer Ingelheim España
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Gedeon Richter
- Servier
- Novartis Farmacéutica
- Sun Pharma
- Nordic Pharma Group
- National Institutes of Health
- UCB US
- Cilag