Corticotroph Tumour Type Influences Clinical Behaviour in Patients With Nonfunctioning Pituitary Neuroendocrine Tumours
The results indicate that cell lineage differentiation in NF-PitNETs/NFPAs influences clinical behaviour. Patients with SCTs were younger at the time of surgery, and harbouring a SCT was associated with an increased likelihood of having postoperative pituitary failure. These findings emphasise the importance of routine immunohistochemical analyses of anterior pituitary hormone and transcription factor expression to identify silent corticotroph tumours.
Authors
- Johan Wikström (ORCID: https://orcid.org/0000-0002-9481-6857)
- Olivera Casar‐Borota (ORCID: https://orcid.org/0000-0001-7376-7331)
- Eva Rask (ORCID: https://orcid.org/0000-0002-3425-8195)
- Nasrin Al‐Shamkhi (ORCID: https://orcid.org/0000-0001-7056-0001)
- Britt Edén Engström (ORCID: https://orcid.org/0000-0003-4514-5193)
- Olafur Gudjonsson
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Örebro University (SE)
- Department of Medical Sciences (RU)
Publication Details
- Journal
- Endocrinology Diabetes & Metabolism
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1002/edm2.70143
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Akademiska Sjukhuset
- Uppsala Universitet