Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer
SFRP2 localizes to tumor, TAMs and TILs in the tumor microenvironment and is negatively associated INF-ƴ in human tumors. hSFRP2 mAb reduces primary and metastatic TNBC growth, increases INF-ƴ from TAMS, boosts the M1/M2 ratio in lung metastases, and induces apoptosis in doxorubicin-resistant cells.
Authors
- Ann‐Marie Broome (ORCID: https://orcid.org/0000-0002-2384-5212)
- Elizabeth C. O’Quinn
- Eleanor Hilliard
- Nancy Klauber‐DeMore
- Michael C. Ostrowski (ORCID: https://orcid.org/0000-0003-2948-6297)
- Shikhar Mehrotra (ORCID: https://orcid.org/0000-0002-5411-9504)
- Patrick Nasarre (ORCID: https://orcid.org/0000-0001-6910-9264)
- Paramita Chakraborty (ORCID: https://orcid.org/0000-0002-0320-8697)
- Nathaniel Oberholtzer (ORCID: https://orcid.org/0000-0002-9080-5130)
- Rachel A. Burge (ORCID: https://orcid.org/0000-0001-9363-4333)
- G. Aaron Hobbs (ORCID: https://orcid.org/0000-0002-4751-9681)
- Julie B. Siegel (ORCID: https://orcid.org/0000-0002-9635-5759)
- Rupak Mukherjee (ORCID: https://orcid.org/0000-0003-3955-7116)
- Mohamed Faisal Kassir (ORCID: https://orcid.org/0000-0003-3501-1802)
- Olivia Sweatt
- Lillian Y. F. Hsu
Institutions
- Medical University of South Carolina (US)
- MUSC Hollings Cancer Center (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s13058-025-02176-6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- University of South Carolina
- National Institutes of Health
- Hollings Cancer Center, Medical University of South Carolina
- National Institute of General Medical Sciences