Case Report: Successful Surgical Resection of PVTT Vp4 Hepatocellular Carcinoma Following Hepatic Arterial Infusion Chemotherapy Combined with Cadonilimab Plus Donafenib
The integrative treatment strategy combining HAIC with cadonilimab and donafenib demonstrates considerable promise as a conversion approach for patients with traditionally unresectable HCC with Vp4-type PVTT. This regimen may substantially improve oncological outcomes and enable curative resection. This case provides compelling evidence to support further clinical investigation of this multimodal therapeutic combination.
Authors
- Yongguang Wei (ORCID: https://orcid.org/0000-0002-2482-5619)
- Hao Su (ORCID: https://orcid.org/0000-0003-0348-9828)
- Xiwen Liao (ORCID: https://orcid.org/0000-0002-1724-1463)
- Guangzhi Zhu (ORCID: https://orcid.org/0000-0001-5958-7289)
- Tao Peng (ORCID: https://orcid.org/0000-0001-6133-7078)
- Chengkun Yang (ORCID: https://orcid.org/0000-0001-6109-7334)
- S.L. Chen
- Chuangye Han
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Pharmacogenomics and Personalized Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/pgpm.s555061
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University