Understanding the influence of transfusion and blood loss on tranexamic acid concentration in scoliosis surgery with blood loss
Sustaining TXA concentrations >10 μg/mL is essential for antifibrinolytic efficacy and haemostatic outcomes. The dilutional impact of PRBC transfusion underscores the need for intraoperative dose adjustment. Optimizing TXA dosing requires understanding pharmacokinetics and patient variability.
Authors
- Marcela A. Segundo (ORCID: https://orcid.org/0000-0003-2938-0214)
- Paula Sá (ORCID: https://orcid.org/0000-0002-2055-3759)
- Eugénia Cruz (ORCID: https://orcid.org/0000-0002-4801-5047)
- Luísa Barreiros (ORCID: https://orcid.org/0000-0003-3481-5809)
- Sibylle Langenecker (ORCID: https://orcid.org/0000-0001-5408-7314)
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- Instituto Superior de Contabilidade e Administracao do Porto (PT)
- Universidade do Porto (PT)
- Hospital de Santo António (PT)
- Rede de Química e Tecnologia (PT)
- Polytechnic Institute of Porto (PT)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1002/bcp.70402
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade do Porto
- Fundação para a Ciência e a Tecnologia