Synthesis of Benzothiazolopyrimidine Diastereomers Through a Copper‐Catalyzed Azide–Alkyne Cycloaddition/Ring‐Cleavage/[4 + 2] Cycloaddition Sequence
Copper‐catalyzed reactions of 2‐benzothiazolimines, terminal ynones, and sulfonyl azides afforded benzothiazolopyrimidine diastereomers. The transformation involved a tandem CuAAC/ring‐cleavage/[4 + 2] cycloaddition procedure with one‐pot synthesis under mild conditions. The benzothiazolopyrimidine diastereomers could be isolated, and their structure is confirmed by X‐ray single‐crystal diffraction.
Authors
- Ao Qi
- Qiaoli Luo
- Weiguang Yang (ORCID: https://orcid.org/0000-0002-7983-2576)
- Xiaoyan Su (ORCID: https://orcid.org/0000-0001-6132-6969)
- Hua Ye (ORCID: https://orcid.org/0000-0001-9930-6023)
- Hang Li (ORCID: https://orcid.org/0000-0002-3694-4463)
- Liu Yang (ORCID: https://orcid.org/0000-0002-3034-6980)
- Jing Shen (ORCID: https://orcid.org/0000-0002-4566-5925)
- Zixin Huang (ORCID: https://orcid.org/0000-0002-6529-8691)
Institutions
- Lingnan Normal University (CN)
- Guangdong Medical College (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1002/ejoc.202500714
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00